Week 6 may not include the NFL’s two undefeated teams, the Minnesota Vikings and Kansas City Chiefs, in action, but there’s still plenty of drama to go around.

On Thursday Night Football, Geno Smith and the 3-2 Seattle Seahawks host Brock Purdy and an underperforming 2-3 San Francisco 49ers team.

On Sunday, the NFL’s International series continues as the Trevor Lawrence and the Jacksonville Jaguars, London’s de facto home team, take on the Chicago Bears and first overall pick Caleb Williams.

In the Sak Sports Blog Game of the Week, Jayden Daniels and the Washington Commanders will put their 4-1 record to the test against a strong 3-2 Baltimore Ravens team, led by perennial MVP candidate Lamar Jackson.

On Sunday Night Football, Joe Burrow and the 1-4 Cincinnati Bengals travel to MetLife Stadium to take on Daniel Jones and the New York Giants (an odd primetime matchup, but anything could happen with a desperate Bengals team against a Giants team that put together a decent win against the Seahawks last week.)

Finally, to round out Week 6 on Monday Night Football, a pivotal AFC East matchup will take place: Josh Allen and the 3-2 Buffalo Bills taking on Aaron Rodgers and the 2-3 New York Jets, who are desperately looking to save their season after firing head coach Robert Saleh. The game will also be played at MetLife Stadium, and as someone who used to work gamedays there, I don’t envy the staff’s position at all: hosting back-to-back, sold-out, primetime football games.

Read on for my 2024-25 NFL Week 6 Picks, and if you’d like to debate or discuss any predictions, join the conversation with @SakSports on X/Twitter or Facebook.

Picks Record

Week 5 Picks: 9-5

Week 1: 13-3

Week 2: 7-9

Week 3: 8-8

Week 4: 10-6

Week 5: 9-5

Overall Record: 47-31 (60.2%)

Thursday Night Football

San Francisco 49ers (2-3) at Seattle Seahawks (3-2): Seahawks win 23-20

Sunday Games

Photo: Chris Graythen/Getty Images

Game in London: Jacksonville Jaguars (1-4) vs. Chicago Bears (3-2): Jaguars win 24-20

Arizona Cardinals (2-3) at Green Bay Packers (3-2): Packers win 30-23

Indianapolis Colts (2-3) at Tennessee Titans (1-3): Colts win 24-17

Houston Texans (4-1) at New England Patriots (1-4): Texans win 33-16

Tampa Bay Buccaneers (3-2) at New Orleans Saints (2-3): Buccaneers win 27-17

Cleveland Browns (1-4) at Philadelphia Eagles (2-2): Eagles win 26-17

Sak Sports Blog Game of the Week Washington Commanders (4-1) at Baltimore Ravens (3-2): Ravens win 33-23

Los Angeles Chargers (2-2) at Denver Broncos (3-2): Broncos win 20-17

Pittsburgh Steelers (3-2) at Las Vegas Raiders (2-3): Steelers win 24-16

Detroit Lions (3-1) at Dallas Cowboys (3-2): Cowboys win 27-24

Atlanta Falcons (3-2) at Carolina Panthers (1-4): Falcons win 30-20

Sunday Night Football

Cincinnati Bengals (1-4) at New York Giants (2-3): Bengals win 34-22

Monday Night Football

(Photo: Sporting News)

Buffalo Bills (3-2) at New York Jets (2-3): Bills win 27-24

Teams on Bye

Kansas City Chiefs (5-0), Minnesota Vikings (5-0), Los Angeles Rams (1-4), Miami Dolphins (2-3)

SEE ALSO: Post-Week 5 Power Rankings

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