Week 5 of the 2024-25 NFL Season brings plenty of heavy-hitting and interesting matchups. Some teams are pushing for red-hot 4-1 or even 5-0 starts, while other playoff hopefuls are hoping to not fall in to ugly 1-4 or 2-3 holes early in the season.

Week 5 kicks off with Thursday Night Football as Baker Mayfield and the 3-1 Tampa Bay Buccaneers hit the road to take on Kirk Cousins and the 2-2 Atlanta Falcons in an important early season NFC South tilt.

Early on Sunday morning, NFL fans across the pond in the United Kingdom will be treated to a great matchup: Aaron Rodgers and the 2-2 New York Jets taking on their former quarterback, Sam Darnold, and his undefeated, 4-0 Minnesota Vikings at Tottenham Hotspur Stadium in London.

Throughout Sunday’s normal, state-side slate, the 2-2 Baltimore Ravens will look to put the 1-3 Cincinnati Bengals in a tough situation, Jayden Daniels and the Washington Commanders look to improve to 4-1 with a win at home over the 1-3 Cleveland Browns, and in the Sak Sports Blog Game of the Week, Josh Allen and the 3-1 Buffalo Bills take on C.J. Stroud and the 3-1 Houston Texans, in Houston, in an early battle for AFC supremacy.

Finally, in a juicy pair of primetime games, Dak Prescott and the 2-2 Dallas Cowboys will look to shake off a so-so start to the season, against Justin Fields and an upstart 3-1 Pittsburgh Steelers squad. On Monday Night Football, a 2-2 but high-powered New Orleans Saints team travels to Kansas City to take on Patrick Mahomes and the defending Super Bowl Champions. The Kansas City Chiefs are 4-0, but how far can they push their undefeated start as the offense loses weapons left and right?

Read on for my 2024-25 NFL Week 5 Picks, and if you’d like to debate or discuss any predictions, join the conversation with @SakSports on X/Twitter or Facebook.

Picks Record

Week 4 Picks: 10-6

Week 1: 13-3

Week 2: 7-9

Week 3: 8-8

Week 4: 10-6

Overall Record: 38-26 (59.4%)

Thursday Night Football

(Photo: Sporting News)

Tampa Bay Buccaneers (3-1) at Atlanta Falcons (2-2): Falcons win 26-22

Sunday Games

(Photo: NYJets.com)

Game in London: New York Jets (2-2) Vs. Minnesota Vikings (4-0): Vikings win 27-24

Carolina Panthers (1-3) at Chicago Bears (2-2): Bears win 17-13

Baltimore Ravens (2-2) at Cincinnati Bengals (1-3): Ravens win 26-23

Miami Dolphins (1-3) at New England Patriots (1-3): Patriots win 23-16

Cleveland Browns (1-3) at Washington Commanders (3-1): Browns win 23-20

Indianapolis Colts (2-2) at Jacksonville Jaguars (0-4): Jaguars win 30-24

Sak Sports Blog Game of the Week Buffalo Bills (3-1) at Houston Texans (3-1): Bills win 33-26

Las Vegas Raiders (2-2) at Denver Broncos (2-2): Broncos win 17-16

Arizona Cardinals (1-3) at San Francisco 49ers (2-2): 49ers win 27-20

Green Bay Packers (2-2) at Los Angeles Rams (1-3): Packers win 28-20

New York Giants (1-3) at Seattle Seahawks (3-1): Seahawks win 26-17

Sunday Night Football

(Photo: Cowboys Wire/USA Today)

Dallas Cowboys (2-2) at Pittsburgh Steelers (3-1): Cowboys win 30-24

Monday Night Football

(Photo: Sports Illustrated)

New Orleans Saints (2-2) at Kansas City Chiefs (4-0): Chiefs win 26-23

Teams on Bye

Detroit Lions (3-1), Tennessee Titans (1-3), Philadelphia Eagles (2-2), Los Angeles Chargers (2-2)

SEE ALSO: Post-Week 4 Power Rankings

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