NFL 2025: Week 4 Picks

The fourth week of the 2025-26 NFL season brings some great matchups, and the stakes are starting to get a little bigger, with some playoff-hopeful teams looking to avoid 1-3 or even 0-4 records, while the league’s best teams are already looking for their third or fourth victory of the season.

One of the biggest games of the week features two 1-2 teams: the Baltimore Ravens and Kansas City Chiefs. Both teams have been perirenal AFC powerhouses, jostling for position for the top seed in the postseason most years. But due to poor starts, one team will have to walk away from Week 4 with a 1-3 record and an uphill battle to face for the rest of the season: will it be Lamar Jackson’s Ravens or Patrick Mahomes’ Chiefs?

Then, there’s a clash of two 3-0 teams with playoff aspirations in the NFC: the defending NFC East and Super Bowl 59 champions, the Philadelphia Eagles, and the defending NFC South champion Tampa Bay Buccaneers. Both teams survived Week 3 by the skin of their teeth to get to 3-0, but only one team will be undefeated heading into Week 5, with temporary control of the NFC’s top seed moving forward.

Elsewhere, a Thursday Night Football matchup between Kyler Murray’s Arizona Cardinals and Sam Darnold’s Seattle Seahawks will give one team a 3-1 record, as will an early Sunday morning London matchup between the Minnesota Vikings and Pittsburgh Steelers.

To cap off the week on Monday Night Football, the winless New York Jets and Miami Dolphins will square off, along with Bo Nix and the 1-2 Denver Broncos trying to get back on track at home against Jake Browning and the 2-1 Cincinnati Bengals.

Read on for my 2025-26 NFL Week 4 Picks, and if you’d like to debate or discuss any picks, join the conversation with @SakSports on Twitter/X, on Facebook, or by commenting directly on this post!

Picks Record

Week 1: 10-6

Week 2: 13-3

Week 3: 11-5

Overall Record: 34-14 (71%)

For three straight weeks, I’ve hit double digit wins, for a strong 71% winning percentage. Use my picks or make your own on DraftKings and sign up with my referral link for free bonus bets for both of us!

Note: I am not sponsored by DraftKings, this is my personal referral link, and I do not personally recommend gambling your own money beyond bonus bets. If you choose to bet, please do so responsibly. I am not responsible for any bets made based on my predictions.

Thursday Night Football

Seattle Seahawks (2-1) at Arizona Cardinals (2-1): Seahawks win 27-23

Sunday Games

Game in London Minnesota Vikings (2-1) vs. Pittsburgh Steelers (2-1): Steelers win 23-16

Washington Commanders (2-1) at Atlanta Falcons (1-2): Commanders win 30-13

New Orleans Saints (0-3) at Buffalo Bills (3-0): Bills win 33-17

Cleveland Browns (1-2) at Detroit Lions (2-1): Lions win 34-13

Carolina Panthers (1-2) at New England Patriots (1-2): Patriots win 24-20

Los Angeles Chargers (3-0) at New York Giants (0-3): Chargers win 28-16

SEE ALSO: Giants To Start Jaxson Dart, Bench Russell Wilson in Week 4

Sak Sports Blog Game of the Week Philadelphia Eagles (3-0) at Tampa Bay Buccaneers (3-0): While you can easily make the case for Baltimore Ravens-Kansas City Chiefs to be the game of the week, I’m super intrigued by this early NFC clash between two 3-0 teams. The Eagles’ opening schedule has been brutal, and it doesn’t get any easier here. Can Jalen Hurts, Saquon Barkley, and the Eagles keep their hot start going? Or will Baker Mayfield and the Tampa Bay Buccaneers be the ones to improve to 4-0? Both teams are coming off fourth quarter comeback wins fueled by blocked kicks. Philadelphia should have the edge here, but it’ll likely come down to the wire once again. Eagles win 27-24

Tennessee Titans (0-3) at Houston Texans (0-3): Texans win 24-17

Indianapolis Colts (3-0) at Los Angeles Rams (2-1): Rams win 27-23

Jacksonville Jaguars (2-1) at San Francisco 49ers (3-0): 49ers win 17-14

Baltimore Ravens (1-2) at Kansas City Chiefs (1-2): Ravens win 26-23

Chicago Bears (1-2) at Las Vegas Raiders (1-2): Raiders win 30-20